Innovative Methodology Compact Movable Microwire Array for Long-Term Chronic Unit Recording in Cerebral Cortex of Primates

Chronic Unit Recording in Cerebral Cortex of Primates Compact Movable Microwire Array for Long-Term

Compact movable microwire array for long-term chronic unit recording in cerebral cortex of primates.

We describe a small, chronically implantable microwire array for obtaining long-term unit recordings from the cortex of unrestrained nonhuman primates. After implantation, the depth of microwires can be individually adjusted to maintain large-amplitude action potential recordings from single neurons over many months. We present data recorded from the primary motor cortex of two monkeys by auton...

A compact moveable microwire array for long-term chronic unit recording in cerebral cortex of primates

We describe a small, chronically implantable microwire array for obtaining long-term unit recordings from the cortex of unrestrained non-human primates. After implantation, the depth of microwires can be individually adjusted to maintain large-amplitude action potential recordings from single neurons over many months. We present data recorded from the primary motor cortex of two monkeys by auto...

Long-term neural recording characteristics of wire microelectrode arrays implanted in cerebral cortex.

This paper describes a detailed protocol for obtaining chronic, multi-site unit recordings in cerebral cortex of awake animals for periods of three months or more. The protocol includes details for making relatively simple and inexpensive implantable multichannel electrodes that consist of arrays of separate microwires. The results reported in this paper suggest that a viable implant will have ...

A Chronically Implantable Bidirectional Neural Interface for Non-human Primates

Optogenetics has potential applications in the study of epilepsy and neuroprostheses, and for studies on neural circuit dynamics. However, to achieve translation to clinical usage, optogenetic interfaces that are capable of chronic stimulation and monitoring with minimal brain trauma are required. We aimed to develop a chronically implantable device for photostimulation of the brain of non-huma...